Modulación de circuitos neuronales como estrategia terapéutica emergente en los trastornos psicóticos: una revisión de alcance

Paola Stephania García-García; Carolina Milena Rosero-Botina; Khaterin Roxana Jaramillo-Lasso; Manuel Alberto Cañas-Salcedo; Engy Estefania Urueña-Sabogal; Luis Hernando Arevalo-Navarro; Sherim Adriana Mercado-Marchena; Daniela Terán-Quintero; Jessica Del Pilar Castellanos-Hernandez; Julian Andres Gomez-Torres

Authors

García-García Paola Stephania Universidad Cooperativa de Colombia. Pasto, Colombia. https://orcid.org/0009-0008-5085-6268
Rosero-Botina Carolina Milena Universidad del Cauca. Popayán, Colombia. https://orcid.org/0009-0002-2092-1432
Jaramillo-Lasso Khaterin Roxana Universidad Cooperativa de Colombia. Medellín, Colombia. https://orcid.org/0009-0002-2092-1432
Cañas-Salcedo Manuel Alberto Universidad de Sucre. Sincelejo, Colombia. https://orcid.org/0009-0009-1674-0664
Urueña-Sabogal Engy Estefania Universidad Surcolombiana. Neiva, Colombia. https://orcid.org/0009-0007-9771-1210
Arevalo-Navarro Luis Hernando Universidad San Martin. Pasto, Colombia. https://orcid.org/0009-0005-4826-2274
Mercado-Marchena Sherim Adriana Universidad Simón Bolívar. Barranquilla, Colombia. https://orcid.org/0009-0006-7148-3435
Terán-Quintero Daniela Fundación Universitaria Juan N Corpas. Bogotá, Colombia. https://orcid.org/0009-0004-6305-4572
Castellanos-Hernandez Jessica Del Pilar Universidad Pedagógica y Tecnológica de Colombia. Tunja, Colombia. https://orcid.org/0009-0006-7983-1692
Gomez-Torres Julian Andres Fundación Universitaria de Ciencias de la Salud. Bogotá, Colombia. https://orcid.org/0009-0008-7216-9514

Keywords:

Schizophrenia. Psychotic Disorders. Neuromodulation. Transcranial Magnetic Stimulation. Magnetic Resonance Imaging

Abstract

DOI: https://doi.org/10.46296/gt.v9i18.0401

Abstract

Psychosis was reinterpreted as a disturbance of distributed networks rather than as a phenomenon explained only by neurotransmitters. This scoping review mapped evidence on invasive and noninvasive neuromodulation directed at neural circuits in psychotic disorders. Reproducible searches were designed for PubMed/MEDLINE, Scopus, Embase, ScienceDirect/Elsevier and UpToDate, the latter only as secondary clinical context. Evidence was most consistent for repetitive transcranial magnetic stimulation in auditory hallucinations and negative symptoms, and more preliminary for electrical stimulation, deep brain stimulation and focused ultrasound. Methodological heterogeneity, small samples and limited connectivity-guided personalization persisted. Circuit-based neuromodulation emerged as a promising field, but still complementary to standard treatment.

Keywords: Schizophrenia. Psychotic Disorders. Neuromodulation. Transcranial Magnetic Stimulation. Magnetic Resonance Imaging.

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References

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CIRCUIT-BASED NEUROMODULATION AS AN EMERGING THERAPEUTIC STRATEGY FOR PSYCHOTIC DISORDERS: A SCOPING REVIEW

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